Hypercholesterolemia and hepatic steatosis in mice fed on low-cost high-fat diet - doi: 10.4025/actascihealthsci.v35i1.10871

Hypercholesterolemia and hepatic steatosis in mice fed on low-cost high-fat diet - doi: 10.4025/actascihealthsci.v35i1.10871

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To verify whether high-fat diet prepared from commercial diet plus chocolate, roasted peanuts and corn cookies induces hypercholesterolemia in mice and whether there is any hepatic involvement in this rosy teacup dogwood type of animal testing.Swiss mice received a high-fat diet for 15 and 30 days; plasma cholesterol, triglycerides and glucose rates were determined.Hepatic impairment was evaluated by histopathological royal nomadic 5413 rug analysis.Cholesterol levels increased 43% in animals treated with high-fat diet for 30 days.Further, histopathological analysis revealed that treatment of animals for 15 and 30 days produced hepatic steatosis and steatohepatitis, respectively.

Experimental model is suitable for assessing the action of anti-hypercholesterolemia and the treatment of steatohepatitis.